I generally see this when there is something wrong with the STL file, like non-manifold geometry or inverted normals. Most FDM slicers like Cura, slic3r, or Simplify3D will complain a lot about STLs that have problems like this, but Creation Workshop has very few warnings.
You can read up more about this kind of issue at:
http://www.shapeways.com/tutorials/fixing-non-manifold-models
http://www.shapeways.com/tutorials/how_to_use_meshlab_and_netfabb
In most cases, you can use Netfabb Cloud to automatically repair these kinds of problems, although occasionally the result will create gaps or unintended shapes.